Dry Vitamin A Palmitate 500

Dry Vitamin A Palmitate 500

Vitamin A Palmitate（IU/g）: 500,000

Chemical Names: Retinyl palmitate, all-trans retinol palmitic acid ester

CAS: 79-81-2

Molecular Formula: C36H60O2

Molecular Weight: 524.9g/mol

EINECS NO. 201-228-5

Description: Free-flowing light yellow powder consisting of fine spherical particles.

Composition:

The special particles contain Vitamin A palmitate in droplets of 1­—2μm embedded in a matrix of gum Arabic and sucrose coated with starch. The products contain t-butylhydroxytoluene(BHT, E321)and DL-α-tocopherol(E307)as an antioxidant..

Solubility: Dispersible in warm water (35-40℃), to form a milky emulsion.

Specification:

Assay: Min.500,000I.U.Vitamin A (=150,000RE) per gram

Absorbance Ratios: Comply with Ph. Eur. and USP

Loss on drying: max.5% (4 hours at 105℃)

Monographs:

The vitamin complies with the current Ph., Eur., USP, FCC monographs.

Particle-size distribution:

100 % smaller than 425μm (40mesh USP)

min. 90% smaller than 250μm (60mesh USP)

max. 15% smaller than 150μm (100mesh USP)

Bulk density: Approx. 0.6g/ml

Stabilization/Stability:

The products are stabilized with BHT(E 321)and DL-α-tocopherol(E307). The stability of the vitamin A in the dry spherical particles is very good even in the presence of minerals. The products have good resistance to pressure and very little vitamin A is expressed during tabletting, so that they exhibit good stability in tablets. The product is stable for at least 24 months, when it is stored in the original containers at room temperature (about 25℃) with dry place.

Applications:

Pharmaceutical preparations:

It is recommended to use the palmitate form of the vitamin if it may be expected to encounter severe stress during processing or storage. As the palmitate of vitamin A is the ester with the best resistance to hydrolysis, it is recommended particularly for preparations with a high moisture content, and for preparations that are to be stored in climates with a high relative humidity. It is equally suitable for multivitamin/mineral tablets and hard gelatin capsules.

Packaging … 5-25kg fibreboard box with AL-PE laminated liner, heat-sealed

Storage … as Vitamin A is sensitive to atmospheric oxygen, light, moisture and heat, the product should be stored in the original containers at room temperature (about 25℃) with dry place

Shelf life …24 months